SARS-CoV-2 in eight municipalities of the Colombian tropics: high immunity, clinical and sociodemographic outcomes
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https://doi.org/10.1093/trstmh/trab094Date
2021Author
Garay, Evelin
Serrano Coll, Hector
Rivero, Ricardo
Gastelbondo, Bertha
Faccini Martinez, Alvaro
Berrocal, Jose
Perez, Alejandra
Badillo, Maria
Martinez Bravo, Caty
Botero, Yesica
Arrieta, German
Calderon, Alfonso
Galeano, Ketty
Lopez, Yesica
Miranda, Jorge
Guzman, Camilo
Contreras, Veronica
Arosemena, Alejandra
Contreras, Hector
Brango Tarra, Eimi
Oviedo Pastrana, Misael Enrique
Mattar, Salim
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Oxford University PressPalabras clave
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Abstract
Serological evaluation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an alternative that allows us to determine the prevalence and dynamics of this infection in populations. The goal of this study was to determine the clinical and sociodemographic dynamics of SARS-CoV-2 infection in a region of the Colombian Caribbean.Between July and November 2020, a cross-sectional observational study was carried out in Córdoba, located in northeast Colombia in the Caribbean area. Eight municipalities with the largest populations were chosen and 2564 blood samples were taken. A commercial enzyme-linked immunosorbent assay was used with the recombinant protein antigen N of SARS-CoV-2. The people included in the study were asked for sociodemographic and clinical data, which were analysed by statistical methods.A seroprevalence of 40.8% was obtained for SARS-CoV-2 in the Córdoba region. In the bivariate analysis, no differences were observed in seropositivity against SARS-CoV-2 for gender or age range (p>0.05). Higher seropositivity was found in low socio-economic status and symptomatic patients (p<0.0001). A total of 30.7% of the asymptomatic patients were seropositive for SARS-CoV-2, which could be linked to the spread of this infection. In the multivariate analysis, seroconversion was related to poverty and clinical manifestations such as anosmia and ageusia (p<0.05).The high seropositivity in Córdoba is due to widespread SARS-CoV-2 in this population. The relationship between seropositivity and socio-economic status suggests a higher exposure risk to the virus caused by informal economic activities in low-income groups. Clinical manifestations such as anosmia and ageusia could be clinical predictors of infection by the new emergent coronavirus.
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Transactions of The Royal Society of Tropical Medicine and Hygiene; Vol. 116, Núm. 116 (2021):Transactions of The Royal Society of Tropical Medicine and Hygiene;p. 139 -147.
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